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通过溶剂热-溶液挥发法合成得到了2个基于依诺沙星(HEx)的稀土配合物[Ce(Ex)4].39H2O(1)和[Sm2(Ex)4(HEx)2(ox)].24H2O(2),并运用红外光谱、元素分析和X-射线单晶衍射等研究手段表征了它们的结构。研究结果表明:配合物1为单核配合物;配合物2为双核配合物。紫外滴定和荧光滴定研究结果表明:它们均能以插入的方式作用于小牛胸腺DNA,结合常数(Kb)分别为4.45×104和6.56×104mol-1.L;抗菌实验结果表明它们对革兰氏菌和真菌的活性均要优于依诺沙星配体本身。
Two rare earth complexes based on enoxacin (HEx) [Ce (Ex) 4], 39H2O (1) and [Sm2 (Ex) 4 (HEx) 2 (ox) were synthesized by solvothermal- ] .24H2O (2), and their structures were characterized by means of IR, elemental analysis and X-ray single crystal diffraction. The results show that: Complex 1 is a mononuclear complex; Complex 2 is a dinuclear complex. UV titration and fluorescence titration results show that: they can act on the insertion of calf thymus DNA, the binding constant (Kb) were 4.45 × 104 and 6.56 × 104mol-1.L; antibacterial results show that they are Gram Fungi and fungi activity are better than enoxacin ligand itself.