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目的研究含对乙酰氨基酚的西药对乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片及中成药柴芩清宁胶囊对脂多糖(LPS)及干酵母大鼠发热模型的解热作用。方法制备大鼠100μg/kg LPS及20%干酵母发热模型;乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片高、中、低剂量分别为205.67、102.83、51.42 mg/kg,以对乙酰氨基酚计;柴芩清宁胶囊高、中、低剂量分别为1110.60、555.30、277.65 mg/kg,以胶囊内容物质量表示,ig给药。观察大鼠体温变化,计算平均最大体温上升高度(T)及体温反应指数(TRI),绘制平均升温曲线。结果对乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片及柴芩清宁胶囊各剂量组对LPS及干酵母大鼠发热模型均具有显著解热作用,且均存在一定剂量效应关系。结论对乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片及柴芩清宁胶囊对LPS及干酵母大鼠发热模型均有一定解热作用,3种西药的解热作用起效快但是作用时间短,而柴芩清宁胶囊表现为起效慢但是作用时间长。
Objective To study the antipyretic effect of Paracetamol-containing Paracetamol Tablets, Compound Paracetamol Tablets, Bupleurum Tablets and Chai Qin Qingning Capsules on LPS-induced fever model in dry yeast rats . Methods 100μg / kg rat LPS and 20% dry yeast fever model were prepared. High, medium and low doses of acetaminophen tablets, compound paracetamol tablets and melatonin tablets were 205.67,102.83,51.42 mg / kg, With paracetamol; Chaiqin Qingning capsule high, medium and low doses were 1110.60,555.30,277.65 mg / kg, the capsule content of the mass, ig administration. Observe the changes of body temperature in rats, calculate the average maximum temperature rise height (T) and body temperature response index (TRI), draw the average temperature curve. Results Acetaminophen tablets, compound paracetamol tablets, bupleurum and Chaiqin Qingning Capsules had significant antipyretic effect on LPS and fever model of dry yeast rats, and all had dose-effect relationship. Conclusions Acetaminophen tablets, compound paracetamol tablets, bupleurum and Chaiqin Qingning capsule have certain antipyretic effect on LPS and fever yeast rat models. The antipyretic effect of the three western medicines is rapid but Short duration of action, and Chai Qin Qingning capsule showed slow onset but the role of a long time.