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[目的]探讨抗癌药物奥沙利铂的不良反应,尤其是临床鲜为报道的变态反应。[方法]对2010年3月至2011年2月采用奥沙利铂为主方案治疗的176例胃肠道肿瘤患者的临床资料进行回顾性分析。[结果]除常见神经毒性、消化道反应、骨髓抑制外,其中15例(8.5%)患者发生不同程度的变态反应,1例出现过敏性休克。[结论]在含奥沙利铂方案化疗用药期间应密切注意发生变态反应的可能,一旦出现立即给予处理。皮肤试验、预处理、延长给药时间或脱敏疗法在预防奥沙利铂变态反应中的作用仍存在争议。
[Objective] To investigate the adverse reaction of anticancer drug oxaliplatin, especially the clinically less reported allergy. [Methods] The clinical data of 176 gastrointestinal cancer patients treated with oxaliplatin-based regimen from March 2010 to February 2011 were retrospectively analyzed. [Result] Except common neurotoxicity, digestive tract reaction and myelosuppression, 15 patients (8.5%) had different degrees of allergic reaction and 1 had anaphylactic shock. [Conclusion] During the course of chemotherapy with oxaliplatin, close attention should be paid to the possibility of occurrence of allergic reaction, and once emergent treatment is given immediately. The role of skin testing, pretreatment, prolonged administration or desensitization therapy in the prevention of allergic reactions to oxaliplatin remains controversial.