在抗菌素的发展史上,自从Fleming发现青霉素后,先后又开发了链霉素、四环素、粘菌素、氯霉素、红霉素与卡那霉素等等。这些抗生素对于预防及治疗各种由致病菌引起的疾病起了巨大的作用。但是,与此同时,也出现了乱用,助长了耐药菌株的大量产生,甚至某些本来致病性很弱的细菌也引起机会性感染。此外,各种抗菌素都有副作用。这些都要求提供更有效与安全的药物。头孢菌素就是适应此一客观要求而被陆续开发的一种新型抗菌素。它以抗菌范围广、疗效显著、毒性低等特点受到广泛的注意及欢迎。十余年来,头孢菌素有了很大的发展,现将国外有关头孢菌素的进展作一简单的介绍。头孢菌素类抗生素在化学结构上均有共同的母核7氨基头孢霉烷酸(7-ACA)。用化学合成法给 In the history of the development of antibiotics, since Fleming found penicillin, has developed streptomycin, tetracycline, colistin, chloramphenicol, erythromycin and kanamycin and so on. These antibiotics play a huge role in the prevention and treatment of various diseases caused by pathogenic bacteria. However, at the same time, chaotic use has also emerged that has contributed to the production of drug-resistant strains in large quantities. Even some bacteria that are originally poorly pathogenic also cause opportunistic infections. In addition, various antibiotics have side effects. All of these require the provision of more effective and safe medicines. Cephalosporin is to adapt to this an objective requirement has been gradually developed a new type of antibiotics. It is a wide range of antibacterial, significant effect, low toxicity and other characteristics of a wide range of attention and welcome. More than ten years, cephalosporin has made great progress, now the progress of foreign cephalosporins for a brief introduction. Cephalosporins antibiotics in the chemical structure of a common mother nucleus 7 cephalosporins (7-ACA). Chemical synthesis method