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目的:观察蚓激酶对冠脉介入术(PCI)后血纤维蛋白原(Fg)浓度变化的影响。方法:选择经冠脉造影证实冠状动脉存在病变,需行择期PCI 术者共65例,随机分为对照组(n=27)和蚓激酶治疗组(n=38)。术前1周开始用药,观察两组在术前1周,术前1d,术后次日及术后1周浓度的变化。结果:对照组Fg 术后1周与术前1周相比明显增高[(4.83±1.06)vs(3.86±0.73)g·L~(-1),P<0.01],与蚓激酶组术后1周相比差异有显著性[(4.83±1.06)vs(4.16±O.87),P<0.05]。蚓激酶组术后1周与术前1周Fg 浓度变化差异无显著性[(4.16±0.87)比(3.98±0.58)g·L~(-1),P<0.05)。结论:PCI 可导致Fg 浓度升高,术前口服蚓激酶可阻止Fg 浓度的升高。
Objective: To observe the effect of lumbrokinase on the changes of fibrinogen (Fg) concentration after percutaneous coronary intervention (PCI). Methods: Coronary artery lesions were confirmed by coronary angiography. A total of 65 patients undergoing elective PCI were randomly divided into control group (n = 27) and lumbrokinase treated group (n = 38). One week before operation, medication was taken and the changes of the two groups were observed at 1 week before operation, 1 day before operation, 1 day after operation and 1 week after operation. Results: The Fg level in the control group was significantly higher than that of the preoperative one week [(4.83 ± 1.06) vs (3.86 ± 0.73) g · L -1, P <0.01] 1 week compared with the difference was significant [(4.83 ± 1.06) vs (4.16 ± 0.87, P <0.05]. There was no significant difference in Fg concentration between 1 week and 1 week before operation in lumbrokinase group (4.16 ± 0.87 vs 3.98 ± 0.58 g · L -1, P <0.05). Conclusion: PCI can lead to the increase of Fg concentration. Preoperative administration of lumbrokinase can prevent the increase of Fg concentration.