目的探讨苯甲酸雌二醇对不育患者子宫内膜的影响作用。方法选择因子宫内膜菲薄而不育的患者88例,既往多次检查,在卵泡破裂日子宫内膜均<6mm者,于月经周期的第8—10天开始监测卵泡,于卵泡长至14mm时给予苯甲酸雌二醇,每天2mg肌肉注射,视卵泡生长及内膜厚度增加情况,可加量至每天10mg,直至卵泡破裂日。第1周期未孕者继续下周期治疗,坚持3周期者纳入观察对象。88例患者共进行224周期治疗。观察子宫内膜厚度及妊娠情况。结果应用苯甲酸雌二醇后内膜厚度明显增加,3个周期中内膜厚度≥8mm的比例分别为63.6%、64.9%、45.2%;总妊娠率为37.5%,周期妊娠率为14.7%。结论苯甲酸雌二醇能明显增加子宫内膜的厚度,提高妊娠率,且价格便宜,使用方便,适宜基层大量应用。 Objective To investigate the effect of estradiol benzoate on the endometrium in infertile patients. Methods Seventy-eight patients with endometrial hyperplasia and infertility were selected and examined many times. In the endometrium with the follicular rupture day less than 6mm, follicles were monitored on the 8th to 10th day of the menstrual cycle, When given benzoate benzoate, intramuscular injection of 2mg daily, depending on follicular growth and increased thickness of the intima, can be added to 10mg daily until the rupture of the follicle. The first cycle of non-pregnant patients continue the next cycle of treatment, adhere to the three cycles were included in the observation. A total of 88 patients underwent 224 cycles of treatment. Endometrial thickness and pregnancy status were observed. Results The thickness of intima increased significantly after administration of estradiol benzoate. The ratio of intima thickness≥8mm in three cycles was 63.6%, 64.9% and 45.2% respectively. The total pregnancy rate was 37.5% and the cycle pregnancy rate was 14.7%. Conclusion Estradiol benzoate can significantly increase the thickness of the endometrium, improve the pregnancy rate, and the price is cheap, easy to use, suitable for a large number of grass-roots applications.