自淋巴细胞杂交瘤技术问世后,各实验室建立了可以分泌抗免疲细胞表面标志的单克隆抗体杂交瘤,它们分泌的单克隆抗体(MAb)为研究免疫细胞的生理功能及细胞表面标志的生物学作用创造了有利的条件。CD_4分子是辅助诱导T 细胞的主要表面标志。本文就近年来应用抗CD_4MAb 对T 细胞发育及生理功能的影响的研究进展作简要介绍。 Since the advent of lymphocyte hybridoma technology, the laboratories have established monoclonal antibody hybridoma secreting anti-fatigue cell surface markers. The monoclonal antibodies (MAbs) secreted by them are used to study the physiological functions of immune cells and cell surface markers Biological effects have created favorable conditions. CD_4 molecules are the main surface markers that assist in the induction of T cells. In this paper, in recent years, the application of anti-CD_4MAb on T cell development and physiological function of the research progress is briefly introduced.