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趋化因子是具有内源性白细胞趋化性和活性化作用的细胞因子。近年研究显示趋化因子及其受体在动脉粥样硬化、充血性心力衰竭及心肌缺血等多种心血管疾病的发生发展过程中发挥极其重要的作用。趋化因子竞争性抗体和受体拮抗剂为上述疾病提供新的有效的干预手段。
Chemokines are cytokines that have endogenous leukocyte chemotaxis and activation. In recent years, studies have shown that chemokines and their receptors play an extremely important role in the occurrence and development of a variety of cardiovascular diseases such as atherosclerosis, congestive heart failure and myocardial ischemia. Chemokine competitive antibodies and receptor antagonists provide new and effective interventions for these diseases.