【摘 要】
：
目的 调查3例携带HLA-DRB1*0114新基因的家系遗传状况.方法 HLA低分辨分型采用PCR-SSO流式分型技术,DNA测序采用等位基因特异性技术.结果 新基因HLA-DRB1*0114序列与DRB1*010
论文部分内容阅读
目的 调查3例携带HLA-DRB1*0114新基因的家系遗传状况.方法 HLA低分辨分型采用PCR-SSO流式分型技术,DNA测序采用等位基因特异性技术.结果 新基因HLA-DRB1*0114序列与DRB1*010101相比,第2外显子区域有3个碱基发生突变,造成2个氨基酸发生改变.257位碱基A→C,导致86编码子的氨基酸由天冬氨酸(Asp)变成丙氨酸(Ala).265位碱基T→C,89编码子的氨基酸由酪氨酸(Tyr)变成组氨酸(His).3个携带HLA-DRB1*0114新基因家系均为陕西籍,HLA-DRB1*0114等位基因携带者都有单倍型A*26-B*37-DRB1*0114,该单倍型均由父亲携带,且都遗传给子代的所有成员.结论 A*26-B*37-DRB1*0114是紧密连锁的单倍型,可以稳定遗传.
其他文献
TOC and color in the bleaching effluent from straw pulp paper process could not reach draining standard after its treatment by a biochemical process. In this st
Solid-liquid hydrocyclones are mainly used to separate large particles, such as the particles of drilling fluid in petroleum industry, and large mineral particl
本研究旨在应用巢式甲基化特异性PCR(nMS-PCR)法检测10种恶性血液系统肿瘤细胞株APC基因启动子的甲基化状态,并探究其在肿瘤发生发展中的作用,同时筛选出APC基因启动子高甲基
Screening of microorganisms producing flocculating substances was carried out. A strain secreting a large amount of bioflocculant was isolated from wastewater s
A dynamical model of temperature of hot smoke layer is quantitatively established based on the whole backdraft procedure induced by liquid fuel. The whole proce
目的:观察rhBMP-2微球温敏型凝胶的药剂学特征及对人牙周膜细胞(PDLCs)增殖的影响。方法:采用W/O/W型乳化溶剂挥发法以聚乳酸-乙醇酸共聚物(PLGA)为材料制备空白微球,通过吸
Tunnel systems in the hilly loess region of northern China are among the largest and most complicated in the world. Tunnel formation and development processes w
RNA interference (RNAi), one of the newly found ways for post-transcriptional gene silencing, has been widely used to investigate gene functions through transge
As the multibarrier system has been adopted to dispose HLW glass in geological formation in many countries, it was important to study the leaching behavior of v
内源性β-葡萄糖醛酸苷酶是溶酶体内的酸性水解酶,主要来源于多形核白细胞,是细胞外基质主要成分大分子蛋白聚糖降解的酶原之一,直接参与细胞外基质的降解过程.由于该酶与肿