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用ＮＴ－Ｏ－ＢＳＡ－ＥＬＬＳＡ方法结合麻风菌素试验对贵州１２个县处于不同治疗阶段的麻风病人的１７１５例接触者进行了亚临床感染检测和临床观察研究。检出抗体阳性者３０６例，其中麻风菌素晚期反应阴性的高危者６１例；经５～９年的临床观察，高危者发病１４例，另有一例抗体阴性者发病。９年的观察组中高危者的发病率是观察５年者的２倍（Ｐ＜０．０５）；家庭内外、治疗前后、不同性别和亲缘关系的接触者中亚感与发病的比率有显著差异。
A total of 1715 contacts of leprosy patients at different treatment stages in 12 counties of Guizhou province were tested for subclinical infection and clinical observation by NT-O-BSA-ELLSA combined with lepirin test. There were 306 cases of positive antibodies, of which 61 cases were at high risk of late reaction negative of lepirin. After 5 to 9 years of clinical observation, 14 cases were at high risk and another case was negative. The incidence of high-risk persons in the 9-year observation group was twice as high as that of the 5-year observation group (P <0.05). Before and after treatment, there was a significant difference between Asian sensation and incidence in the contacts of different genders and relatives difference.