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对清胰化积方的相关研究进行总结分析,概述清胰化积方治疗中晚期胰腺癌的相关机制。清胰化积方以清热解毒、理气化湿为原则,在中晚期胰腺癌的治疗中,可稳定瘤灶、延长生存期。其机制主要表现在下调免疫抑制因子、改善免疫抑制状态、抑制肿瘤相关成纤维细胞、改善肿瘤微环境、下调转移相关基因Ski、降低S期细胞比例进而抑制肿瘤细胞增殖、调节Notch信号通路抑制蛋白表达。
The Qingyin Huaji Fang related research summary analysis, overview Qingyin Huji Decoction treatment of advanced pancreatic cancer related mechanism. Qingyitiaji square to heat detoxification, the principle of Qi and dampness, in the treatment of advanced pancreatic cancer, can stabilize the tumor, prolong survival. The mechanisms are mainly down-regulating immunosuppressive factors, improving immunosuppressive status, inhibiting tumor-associated fibroblasts, improving tumor microenvironment, down-regulating metastasis-related gene Ski, reducing the proportion of S-phase cells and thereby inhibiting tumor cell proliferation, and regulating Notch signaling pathway inhibitory protein expression.