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目的:探讨膀胱癌肿瘤血管生成与谷胱甘肽蛳S蛳转移酶蛳π(GST蛳π)的相互关系。方法:将82例膀胱癌手术切除标本分成原发组和复发组,应用S蛳P免疫组化法检测GST蛳π、血管内皮生长因子(VEGF)、微血管密度(MVD)的表达情况,将数据作统计学处理。结果:复发组的膀胱癌MVD、VEGF、GST蛳π指数明显高于原发组(P <0.05或P <0.01),VEGF和GST蛳π存在正相关性(P< 0.01),MVD和GST蛳π存在正相关性(P <0.01)。结论:膀胱癌VEGF高表达在肿瘤血管生成中起重要作用,VEGF和MVD与GST蛳π在诱导膀胱癌耐药方面可能存在着协同机制,VEGF、MVD与GST蛳π在膀胱癌中的联合检测对判断肿瘤的生物学行为和预后及化疗药物的敏感性预测有重要意义。
Objective: To investigate the relationship between angiogenesis and glutathione S-transferase 蛳 π (GST 蛳 π) in bladder cancer. Methods: 82 cases of bladder cancer resected specimens were divided into primary group and recurrent group. The expression of GST 蛳 π, VEGF and MVD was detected by immunohistochemical method. The data Statistical analysis. Results: MVD, VEGF, GST 蛳 π in bladder cancer were significantly higher in relapsed group than those in primary group (P <0.05 or P <0.01), but there was a positive correlation between VEGF and GST 蛳 π (P <0.01) π has a positive correlation (P <0.01). Conclusion: The high expression of VEGF in bladder cancer plays an important role in tumor angiogenesis. There may be a synergistic mechanism between VEGF and MVD and GST 蛳 π in the induction of bladder cancer. The combined detection of VEGF, MVD and GST 蛳 π in bladder cancer To determine the biological behavior of the tumor prognosis and chemotherapeutic drug sensitivity prediction is of great significance.