目的　探讨胃癌的分子生物学研究进展。方法　回顾国内外有关文献。结果　胃癌的发生、进展与癌基因、生长因子、细胞周期调节蛋白、肿瘤抑制基因、细胞粘附因子及基因的不稳定性有关。结论　胃癌涉及多种基因的不同改变。 Objective To explore the progress of molecular biology in gastric cancer. Methods Review domestic and foreign literature. Results The occurrence and progression of gastric cancer were related to the instability of oncogenes, growth factors, cell cycle regulatory proteins, tumor suppressor genes, cell adhesion factors, and genes. Conclusions Gastric cancer involves different changes in many genes.