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目的 观察先天性胆管扩张症胆囊粘膜的增殖性变化。方法 先天性胆管扩张症患者42例 ,其中儿童 35例 ,成人 7例 ;慢性胆囊炎胆石症成人 2 0例 ,对照组 5例。取石蜡切片行HE和增殖细胞核抗原 (PCNA)染色 ,观测增生形态指标 (即胆囊粘膜皱襞高度、皱襞密度、皱襞细胞密度 )以及PCNA阳性率。结果 胆管扩张症、慢性胆囊炎胆石症患者的增生形态指标及PCNA阳性率均高于对照组 (P <0 .0 5 )。成人胆管扩张症PCNA阳性率高于慢性胆囊炎胆石症 (P <0 .0 5 )。结论 先天性胆管扩张症自幼即存在胆囊粘膜增殖性增高现象 ,成人病例且高于慢性胆囊炎胆石症。
Objective To observe the proliferative changes of gallbladder mucosa in congenital bile duct dilatation. Methods 42 cases of congenital bile duct dilatation, including 35 children, 7 adults; 20 cases of chronic cholecystitis cholelithiasis in adults, the control group of 5 cases. Paraffin sections were stained with hematoxylin and eosin and proliferating cell nuclear antigen (PCNA). Proliferation index (ie, gallbladder mucosa folds height, folds density, follicular cell density) and PCNA positive rate were observed. Results The hyperplasia index and the positive rate of PCNA in patients with bile duct dilatation and chronic cholecystitis were higher than those in control group (P <0.05). The positive rate of PCNA in adult biliary dilatation was higher than that of chronic cholecystitis (P <0.05). Conclusions Congenital bile duct dilatation exists gallbladder mucosa proliferative phenomenon since childhood, adult cases and higher than chronic cholecystitis cholelithiasis.