近年来发现脑缺血后脑组织一氧化氮(NO)含量增高,NO能显著影响缺血后脑水肿及脑梗塞灶的大小,但一氧化碳合成酶(NOS)拮抗剂对脑缺血的影响尚有争论。巴曲酶(batroxobin)为蛇毒酶制剂,我们用巴曲酶治疗急性缺血性脑血管病取得了较好疗效,动物实验也表明巴曲酶可减轻沙土鼠脑缺血后脑水肿程度和卒中症候,但巴曲酶治疗脑缺血是否能直接或间接影响缺血脑组织的NOS基因表达尚未见报道。 In recent years, it was found that the content of nitric oxide (NO) in brain tissue increased after cerebral ischemia, and NO significantly affected the cerebral edema and the size of cerebral infarction. However, the effect of carbon monoxide synthase (NOS) antagonist on cerebral ischemia was controversial . Batroxobin is a snake venom enzyme preparation, we use batroxobin treatment of acute ischemic cerebrovascular disease has achieved good effect, animal experiments also showed that batroxobin can reduce cerebral edema in gerbils after cerebral edema and stroke syndrome , But Batroxobin treatment of cerebral ischemia whether directly or indirectly affect the NOS gene expression in ischemic brain has not been reported.