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由于药物经皮释放系统(TransdermalDelivery System)的给药方式有许多优点,所以被开发研究。但发现很多药物不能以一定的速率经皮给药,使获得有效的血药浓度。因此,经皮释放系统的临床应用,尚受到一定的限制。为降低皮肤的阻力,提高经皮给药的血药浓度,近年来,不少学者又深入研究药物电离子导入疗法,并取得了新进展,使这个古老的给药方式,将成为医药界今后重点研究的课题。(一)体外实验模型的设计:体外实验模型,近来也有很大的改进。一般分给药室(Donor cell)和接受室(Recep-
Due to the many advantages of the drug delivery system, Transdermal Delivery System has been developed. However, many drugs were found not to be transdermally administered at a rate that resulted in an effective plasma concentration. Therefore, the clinical application of transdermal delivery system, is still subject to certain restrictions. In recent years, many scholars have studied drug iontophoresis therapy in depth and made new progress in order to reduce the resistance of the skin and increase the plasma concentration of transdermal drug delivery, so that this ancient drug delivery mode will become the future Key research topics. (A) Design of in vitro experimental models: In vitro experimental models have also been greatly improved lately. General Donor Cell and Recep-