既往认为先天梅毒很少合并肾脏损害。近15年的文献只报道了两种先天梅毒的肾炎类型——肾病综合征和急性肾炎,以前者更为常见。作者研究13例具有临床和血清学证据的先天梅毒患者,年龄22天～3个月,均未见肾病综合征或肉眼血尿,但有2例没有检查尿。余11例患者中,3例发现镜下血尿及蛋白尿(<50mg/kg/d);2例只有蛋白尿。这5例患者中,4例测定血清补体,3例接受了肾活检。其他患者在调查前已应用青霉素治疗,没有发现尿的异常。5例具有尿改变患者的肾功能,包括 Previously congenital syphilis with renal damage rarely. Nearly 15 years of literature only reported two types of congenital syphilis nephritis - nephrotic syndrome and acute nephritis, the former is more common. The authors studied 13 patients with congenital syphilis with clinical and serological evidence, aged 22 days to 3 months, with no nephrotic syndrome or gross hematuria, but 2 without urinalysis. Of the 11 patients, microscopic hematuria and proteinuria (<50 mg / kg / d) were found in 3 cases and proteinuria in 2 cases. Of the 5 patients, serum complement was measured in 4 and renal biopsy in 3. Other patients had been treated with penicillin prior to the survey, and no abnormal urine was found. Five patients had urinary changes in their renal function, including