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1924年Pphillon和Lefevre叙述一例患者,其手掌、足底过度角化并发乳恒牙列之牙周组织早期破坏。此后有关本病之材料在文献中陆续有所记载。笔者遇到同一家庭中之两例此病患者特报道于下:
In 1924 Pphillon and Lefevre described a patient who had early periodontal tissue destruction of the periodontal tissues of the palmar and plantar hyperkeratosis complicated with permanent dentition. Since then the material of this disease have been documented in the literature. The author encountered two cases of the same family in the special report on the following: