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目的探讨雌激素对前列腺基质细胞生长的影响。方法体外分离和培养前列腺基质细胞,细胞计数法及MTT法检测细胞生长情况。结果雌激素在一定浓度范围内促进前列腺基质细胞生长,但浓度继续增加时,前列腺基质细胞生长受抑制。结论雌激素的浓度与前列腺基质细胞生长呈倒U形关系,在一定浓度范围,雌激素刺激基质细胞增殖,否则表现为抑制作用。
Objective To investigate the effect of estrogen on the growth of prostatic stromal cells. Methods Prostate stromal cells were isolated and cultured in vitro. Cell growth was measured by MTT assay. Results Estrogen could promote the growth of prostatic stroma cells in a certain concentration range, but the growth of prostatic stroma cells was inhibited when the concentration of Estrogen increased. Conclusion The estrogen concentration is inversely U-shaped with the growth of prostatic stromal cells. Estrogen stimulates the proliferation of stromal cells in a certain range of concentration, otherwise, it shows an inhibitory effect.