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目的:探讨机械通气联合一氧化氮在新生儿胎粪吸入综合征中的应用效果。方法:选择我院2008年1月至2014年1月84例新生儿胎粪吸入综合征病例作为观察对象,并将2011年9月至2014年1月患儿作为观察组(41例)和2008年1月至2011年8月患儿回顾性分析作为对照组(43例),两组患儿均使用机械通气治疗方法,在此基础上给予观察组患儿一氧化氮进行联合治疗。比较两组患儿临床治疗效果及血气指标变化情况。结果:观察组患儿治疗总有效率为92.7%,显著高于对照组(74.4%),P<0.05;两组患儿血气指标均有显著改善,但观察组患儿治疗后PaO、PaCO2改善程度更加明显。两组差异具有统计学意义,P<0.05。结论:机械通气联合一氧化氮治疗新生儿胎粪吸入综合征,疗效显著,可有效改善患儿血气指标,值得临床推广。
Objective: To investigate the effect of mechanical ventilation combined with nitric oxide in neonatal meconium aspiration syndrome. Methods: 84 cases of neonatal meconium aspiration syndrome from January 2008 to January 2014 in our hospital were selected as the observation subjects. The children from September 2011 to January 2014 were selected as the observation group (41 cases) and 2008 From January to August 2011, retrospective analysis of children as a control group (43 cases), both groups of children were treated with mechanical ventilation, on the basis of observation group were given nitric oxide in combination therapy. The clinical effects and changes of blood gas index in two groups were compared. Results: The total effective rate was 92.7% in the observation group, significantly higher than that in the control group (74.4%), P <0.05. The blood gas indexes of both groups were significantly improved, but the PaO and PaCO2 of the observation group were improved The degree is more obvious. The difference between the two groups was statistically significant, P <0.05. Conclusion: The combination of mechanical ventilation and nitric oxide in the treatment of neonatal meconium aspiration syndrome has significant curative effect, which can effectively improve the blood gas index in children and is worthy of clinical promotion.