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目的分析与评价中医配合磷酸肌酸钠在治疗一氧化碳中毒过程中的疗效,为一氧化碳中毒的治疗提供指导。方法选择2012年6月至2014年12月该院收治的120例一氧化碳中毒患者为研究对象,按照治疗方式不同分为观察组和对照组,每组各60例。对照组患者采用高压氧等常规治疗,观察组患者加用中医药方配合磷酸肌酸钠治疗。比较2组患者治疗前后HDS评分、P300潜伏期、神经功能损伤评分和心肌损伤标志物变化,评价2组患者疗效差异。结果治疗后观察组患者与对照组相比HDS评分明显升高,P300潜伏期明显缩短(P<0.05),NIHSS评分和血清c TNI、CKMB、IMA水平明显降低(P<0.05),观察组患者的治疗效果显著优于对照组(P<0.05)。结论中医配合磷酸肌酸钠治疗一氧化碳中毒能够有效改善心脏和脑组织缺氧状态,减轻神经功能损伤,疗效显著优于单一高压氧常规治疗。
Objective To analyze and evaluate the efficacy of Chinese medicine combined with sodium phosphorylate in the treatment of carbon monoxide poisoning and provide guidance for the treatment of carbon monoxide poisoning. Methods From June 2012 to December 2014, 120 patients with carbon monoxide poisoning who were treated in this hospital were selected as study objects. According to the different treatment methods, the patients were divided into observation group and control group with 60 cases in each group. Patients in the control group were treated with conventional therapy such as hyperbaric oxygen. The patients in the observation group were treated with Chinese medicine and sodium creatine phosphate. HDS score, P300 latency, neurological impairment scores and myocardial injury markers in two groups before and after treatment were compared to evaluate the difference in curative effect between the two groups. Results Compared with the control group, the HDS score of the observation group was significantly increased, the P300 latency was significantly shorter (P <0.05), the NIHSS score and serum c TNI, CKMB and IMA were significantly decreased (P <0.05) The treatment effect was significantly better than the control group (P <0.05). Conclusion Chinese medicine treatment of carbon monoxide poisoning with sodium creatine phosphate can effectively improve the hypoxia state of the heart and brain tissue and reduce neurological damage, and the curative effect is significantly better than that of routine hyperbaric oxygen therapy.