目的研究蒲公英在调节肠道菌群和改善荷瘤小鼠生存质量提高生存率方面的作用。方法用肝癌腹水瘤H22细胞株注射小鼠造荷瘤小鼠模型,然后口服蒲公英提取液治疗。观察治疗前后菌群变化、腹水量和荷瘤生存时间等。结果蒲公英治疗组与阴性对照组比较,肠道菌群趋于平衡、腹水出现时间延迟、腹水量降低和荷瘤生存时间延长。结论蒲公英提取液能调节小鼠肠道菌群,改善荷瘤小鼠生存质量、提高生存率。 Objective To study the role of dandelion in the regulation of intestinal flora and improve the survival quality of tumor-bearing mice. Methods A mouse model of tumor bearing H22 cell line was injected into hepatoma of ascites carcinoma of the liver and then treated with oral dandelion extract. Observe changes in bacterial flora before and after treatment, ascites volume, and tumor survival time. Results Compared with the negative control group, the dandelion treatment group tended to have a balance of intestinal flora, delayed ascites, decreased ascites, and prolonged tumor-bearing survival. Conclusion The dandelion extract can regulate the intestinal microflora of mice, improve the quality of life of tumor-bearing mice, and improve the survival rate.