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缩宫素(oxytocin,OT)在分娩和泌乳中起重要作用,近年OT对神经精神系统发育的影响逐渐受到重视。分娩时主要来源于母体下丘脑的OT通过减少神经元活动及代谢的能量需求,对分娩过程中的胎脑起保护作用。OT同时作为神经递质或神经调质,调节儿童神经精神系统发育,并可能与儿童孤独症、成人社会行为、社会认知障碍相关。研究OT对神经精神系统发育的影响有重要意义。
Oxytocin (OT) plays an important role in labor and lactation. In recent years, the effects of OT on the development of neuropsychopharmacology have been gradually emphasized. OT, which is primarily derived from the maternal hypothalamus at childbirth, protects the fetal brain during childbirth by reducing the energy requirements of neuronal activity and metabolism. OT as a neurotransmitter or neuromodulator, regulate children’s neuropsychiatric system development, and may be related to children with autism, adult social behavior, social cognitive disorders. It is of great significance to study the effect of OT on the development of neuropsychiatric system.