目的观察阿昔洛韦片治疗手足口病的临床疗效。方法将100例小儿手足口病患儿随机分为治疗组和对照组各50例,分别口服阿昔洛韦20mg·kg-1·d-1和利巴韦林10mg·kg-1·d-1,观察临床症状、体征变化并进行分析。结果治疗组总有效率为96.0%高于对照组的82.0%,差异有统计学意义(P<0.05),发热、发热消退及体征消退时间治疗组快于对照组,差异有统计学意义(P<0.05)。结论阿昔洛韦片治疗小儿手足口病安全有效。 Objective To observe the clinical efficacy of acyclovir in the treatment of hand-foot-mouth disease. Methods 100 children with HFMD were randomly divided into treatment group and control group, 50 cases were treated with acyclovir 20mg · kg-1 · d-1 and ribavirin 10mg · kg-1 · d- 1, observe clinical symptoms, signs and changes. Results The total effective rate in the treatment group was 96.0%, which was significantly higher than that in the control group (82.0%) (P <0.05). The treatment group was faster than the control group in fever, fever and signs of regression (P <0.05). Conclusion Acyclovir tablets are safe and effective for the treatment of hand-foot-mouth disease in children.