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目的 探讨胸腺上皮细胞的异质性及甲状腺功能降低时大鼠胸腺上皮细胞的变化。方法 将断乳后 1月的Wistar大鼠分为 2组 :正常组饲以正常饲料 ,饮用自来水 ;低碘组饲以低碘饲料 ,饮用去离子水。饲养 3个月后测定各组大鼠血清甲状腺素及胸腺指数 ,同时对大鼠胸腺进行透射电镜观察。结果 低碘组大鼠血清甲状腺激素及胸腺指数显著降低。胸腺上皮细胞发生了 3种变化 :( 1)细胞角蛋白增多 ;( 2 )囊泡增大和 (或 )小泡增多 ;( 3 )细胞降解。结论 不同部位的胸腺上皮细胞对甲状腺功能低下的反应不同
Objective To investigate the heterogeneity of thymic epithelial cells and the changes of thymic epithelial cells in rats with hypothyroidism. Methods Wistar rats at 1 month after weaning were divided into 2 groups: normal group fed normal feed and drinking tap water; low iodine group fed low iodine feed and drinking deionized water. Three months after feeding, serum thyroxine and thymus index of rats in each group were determined, and the thymus of the rats was observed by transmission electron microscopy. Results Serum thyroid hormone and thymus index in low iodine group rats decreased significantly. Thymic epithelial cells occurred in three changes: (1) increased cytokeratin; (2) vesicles increased and (or) vesicles increased; (3) cell degradation. Conclusions Thymic epithelial cells in different sites respond differently to hypothyroidism