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目的:系统评价定量PCR检测外周血EBV-DNA在诊断鼻咽癌中的作用。方法:检索国内外各数据库,用RevMan软件进行Meta分析。结果:NPC患者外周血EBV-DNA阳性率高于正常人,定量PCR诊断NPC的敏感性和特异性高于EBV-VCA-IgA检测,检测血清或血浆DNA的敏感性高于白细胞,比较均有统计学意义。结论:定量PCR检测外周血EBV DNA在诊断鼻咽癌中具有重要意义。
Objective: To evaluate the role of EBV-DNA in peripheral blood in the diagnosis of nasopharyngeal carcinoma by quantitative PCR. Methods: The databases at home and abroad were searched and analyzed by RevMan software. Results: The positive rate of EBV-DNA in peripheral blood of patients with NPC was higher than that of normal people. The sensitivity and specificity of quantitative PCR in detecting NPC were higher than that of EBV-VCA-IgA, and the sensitivity of detecting serum or plasma DNA was higher than that of white blood cells Statistical significance. Conclusion: Quantitative PCR detection of peripheral blood EBV DNA in the diagnosis of nasopharyngeal carcinoma has important significance.