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应用阳极氧化法在Ti-6Al-4V钛合金(TC4)表面制备了多孔TiO2涂层,在TiO2涂层表面电沉积制备了羟基磷灰石(hydroxyapatite,HA)/TiO2复合涂层,用实验用人工脑脊液(artificial cerebrospinal fluid,ACSF)体液模拟人体的脑脊液,以TC4和TiO2涂层为对比,研究了HA/TiO2涂层在浸泡过程中发生的物理化学变化,考察了HA/TiO2复合涂层抑制钛合金中元素Al和V的析出情况。结果表明:3种样品随浸泡时间的延长遵循的生长规律为:HA成核→HA晶粒长大→HA晶粒相互团簇形成一体→涂层逐渐扩大覆盖到整个基体表面;TC4,TiO2以及HA/TiO2涂层在ACSF中都能够诱导HA的生成,表现出了良好的生物活性。检测浸泡后溶液中Al和V的浓度可知,阳极氧化法制备的TiO2涂层对于Al,V元素的析出起到了一定的抑制作用,能够进一步提高钛合金的生物相容性。
Porous TiO2 coating was prepared on the surface of Ti-6Al-4V titanium alloy (TC4) by anodization method. Hydroxyapatite (HA) / TiO2 composite coating was electrodeposited on the surface of TiO2 coating. The artificial cerebrospinal fluid (ACSF) fluid was used to simulate the cerebrospinal fluid in human body. The TC / TiO2 coating was used as a contrast to study the physico-chemical changes of the HA / TiO2 coating during soaking. The HA / TiO2 coating inhibition Titanium alloy elements Al and V precipitation. The results showed that the growth regularities of the three samples followed the soaking time were: HA nucleation → HA grain growth → HA grains formed one cluster with each other → the coating gradually extended to cover the entire surface of the substrate; TC4, TiO2 and The HA / TiO2 coating can induce the formation of HA in ACSF and showed good bioactivity. It is known that the concentration of Al and V in the solution after immersion shows that the TiO2 coating prepared by the anodic oxidation method has a certain inhibitory effect on the precipitation of Al and V elements and further improves the biocompatibility of the titanium alloy.