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作者于1978年1月~1980年1月,对肝硬化食管静脉曲张出血前保守治疗和预防性硬化治疗,进行前瞻性随机对照试验。经组织学证实的71例肝硬化随机分为2组,2组患者在年龄、性别、肝病史、肝病程度和病理组织学类型方面均相仿,具有可比性。对照组36例,每4个月1次进行临床及上消化道内窥镜随访;硬化治疗组35例,坚持在门诊接受2~4次硬化治疗,每次间隔6~7天,每次经内窥镜于30~50处静脉曲张处周围注射 Aethoxysclerol 0.5~1.0ml。4个月后进行内窥镜对照,若静脉曲张复发或纤维化不良,可重复硬化治疗,6个月后再随访。两组各有3例因失访等原因最后无统计在内。试验期内对照组33例中22例(66%)发生静脉曲
The author from January 1978 to January 1980, the conservative treatment of cirrhotic esophageal varices before bleeding and preventive sclerotherapy, prospective randomized controlled trials. Histologically confirmed 71 cases of cirrhosis were randomly divided into two groups, two groups of patients in age, gender, history of liver disease, liver disease and histological types are similar, comparable. The control group of 36 patients, once every 4 months for clinical and upper gastrointestinal endoscopy follow-up; sclerotherapy group of 35 patients, insisted in the clinic to accept 2 to 4 sclerotherapy, each interval of 6 to 7 days, each time by the internal Endoscopy at 30 to 50 around the injection of intravenous Aethoxysclerol 0.5 ~ 1.0ml. 4 months after endoscopic control, if varicose veins recurrence or poor fibrosis, repeat sclerosis treatment, 6 months after follow-up. There were 3 cases in each group because there was no statistics on the reasons such as the loss of follow-up. In the control group, 22 patients (66%) in the control group developed varicose veins