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目的探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)对母婴结局的影响。方法收集2011年5月至2016年12月在上海交通大学医学院附属苏州九龙医院接受治疗的161例ICP患者为研究组,根据患者的血清总胆汁酸水平将其分为轻度组(116例)与重度组(45例),观察两组患者母婴结局的差异。结果重度组总胆汁酸(total bile acid,TBA)谷丙转氨酶(alanine aminotransferase,ALT)以及谷草转氨酶(aspartate aminotransferase,AST)水平显著高于轻度组,差异有统计学意义(P<0.05),重度组终止妊娠时间和阴道分娩比例显著低于轻度组,差异有统计学意义(P<0.05),轻度组与重度组的产后出血比列、新生儿体重及Apgar评分无明显差别,差异均无统计学意义(P>0.05)。结论妊娠期ICP是导致不良母婴结局的一项重要原因,应加强对产妇的产前检查以及围生期的胎儿监护护理。
Objective To investigate the effect of intrahepatic cholestasis of pregnancy (ICP) on maternal and infant outcomes. Methods A total of 161 ICP patients treated in Suzhou Kowloon Hospital affiliated to Shanghai Jiaotong University School of Medicine from May 2011 to December 2016 were enrolled in this study. Patients were divided into mild group according to their serum total bile acid level (116 cases ) And severe group (45 cases), observe the differences between the two groups of maternal and infant outcomes. Results The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in total bile acid (TBA) group were significantly higher than those in mild group (P <0.05) Severe group of termination of pregnancy and vaginal delivery was significantly lower than the proportion of mild group, the difference was statistically significant (P <0.05), mild and severe group of postpartum hemorrhage than neonatal weight and Apgar score no significant difference, the difference No statistical significance (P> 0.05). Conclusions Pregnancy ICP is an important cause of adverse maternal and infant outcomes. Maternal prenatal care and perinatal fetal care should be strengthened.