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Kahn 等描述了有关抗胰岛素疾病的两个综合征;A 型综合征以脂肪萎缩性糖尿病为特征。B 型综合征多发生于年龄较大的女性,有明显抗胰岛素的特征,常伴黑棘皮症和类似结缔组织疾病的特征,如关节疼痛、脱发、唾液腺肿大、白细胞减少、蛋白尿、高丙种球蛋白血症、抗核抗体和抗 DNA 抗体滴度增高等。此型患者循环血中存在一种阻止胰岛素与细胞膜受体相互作用的抗体。本文测定了14例抗胰岛素病人的自身免疫学特
Kahn et al. Describe two syndromes related to insulin resistance; Type A syndrome is characterized by lipoatrophic diabetes. B-type syndrome mostly occurs in older women with markedly anti-insulin properties, often associated with acanthosis nigricans and similar connective tissue disease characteristics such as joint pain, hair loss, salivary gland enlargement, leukopenia, proteinuria, high Gammaglobulinemia, antinuclear antibodies and anti-DNA antibody titer and so on. There is an antibody in the circulating blood that blocks the interaction of insulin with the cell membrane receptors in this type of patient. This article measured 14 cases of anti-insulin patients with autoimmune special