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目的探讨隐匿性高血压(MH)患者的尿酸(UA)与高敏C-反应蛋白(hs-CRP)水平的相关性。方法随机选择2013年8月至2014年8月血压正常者232例,排除心脑血管病、糖尿病、感染、慢性炎性疾病、自身免疫性疾病及有酗酒史、高嘌呤饮食者。其中经动态血压监测(ABPM)诊断的117例隐匿性高血压患者为MH组,另115例排除高血压诊断的健康者为NBP组,比较分析两组患者UA和hs-CRP的水平。结果与NBP组比较,MH组的UA[(366.60±131.40)μmol/L]及hs-CRP水平[(3.30±2.10)mg/L]明显升高,差异有统计学意义(P<0.05)。MH患者较NBP患者UA和hs-CRP水平高,MH组血清UA与hs-CRP呈正相关(r=0.734,P<0.05)。结论 MH患者体内可能已存在代谢紊乱和血管内皮功能损伤,两者均可能参与了MH的发病机制。
Objective To investigate the correlation between uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) in patients with occult hypertension (MH). Methods A total of 232 patients with normal blood pressure from August 2013 to August 2014 were randomly selected to exclude cardiovascular and cerebrovascular diseases, diabetes mellitus, infections, chronic inflammatory diseases, autoimmune diseases, alcoholism and high purine diet. One hundred and seventy-one patients with occult hypertension diagnosed by ambulatory blood pressure monitoring (ABPM) were MH group, and the other 115 healthy individuals without hypertension were evaluated as NBP group. The levels of UA and hs-CRP in both groups were compared. Results Compared with NBP group, the levels of UA [(366.60 ± 131.40) μmol / L] and hs-CRP in MH group [(3.30 ± 2.10) mg / L] were significantly increased in MH group (P <0.05). The levels of UA and hs-CRP in patients with MH were higher than those in patients with NBP. The levels of serum UA and hs-CRP in MH patients were positively correlated (r = 0.734, P <0.05). Conclusion MH patients may have metabolic disorders and vascular endothelial dysfunction in vivo, both of which may be involved in the pathogenesis of MH.