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目的:研究抑癌基因RECK和MMP-2在涎腺腺样囊性癌中的表达及其相关性,探讨RECK基因的表达在涎腺腺样囊性癌的诊断和预后判断中的价值。方法:应用免疫组化SP染色法检测RECK、MMP-2在涎腺腺样囊性癌、涎腺多形性腺瘤、正常组织中的表达。结果:RECK在涎腺腺样囊性癌中表达明显降低,MMP-2表达明显升高,RECK的阳性表达率和表达强度与病理分型、神经侵犯、TNM分期有关,与患者的年龄和性别无关,RECK与MMP-2的表达呈负相关性,多因素COX回归分析表明RECK的表达及病理类型为判定预后的独立因素。结论:RECK在涎腺腺样囊性癌中明显存在表达降低,RECK的检测可辅助预测患者预后及为患者的综合治疗提供参考。
Objective: To study the expression and correlation of RECK and MMP-2 in salivary adenoid cystic carcinoma and to explore the value of RECK gene expression in the diagnosis and prognosis of salivary adenoid cystic carcinoma. Methods: Immunohistochemical SP staining was used to detect the expression of RECK and MMP-2 in salivary adenoid cystic carcinoma, salivary gland pleomorphic adenoma and normal tissues. Results: The expression of RECK was significantly decreased in salivary adenoid cystic carcinoma and the expression of MMP-2 was significantly increased. The positive rate of RECK expression and its expression were correlated with pathological type, nerve invasion and TNM stage, Independently, the expression of RECK was negatively correlated with the expression of MMP-2. Multivariate COX regression analysis showed that the expression of RECK and pathological type were independent prognostic factors. Conclusions: The expression of RECK is obviously decreased in salivary adenoid cystic carcinoma. The detection of RECK can be used to predict the prognosis of patients and provide a reference for the comprehensive treatment of patients.