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目的探讨SLP-2在皮肤鳞状细胞癌中的表达及其与临床病理参数间的相关性。方法免疫组织化学法观察50例皮肤鳞状细胞癌和30例脂溢性角化病组织蜡片中SLP-2的表达,分析SLP-2蛋白的表达与皮肤鳞状细胞癌临床病理变量之间的关系。结果 SLP-2蛋白在脂溢性角化、皮肤鳞状细胞癌中的阳性表达率分别为6.67%和74.00%。SLP-2蛋白的表达与皮肤鳞癌的病理分级、临床分期及淋巴结转移密切相关。结论 SLP-2蛋白的过表达可能与皮肤鳞状细胞癌的发生发展密切相关。
Objective To investigate the expression of SLP-2 in cutaneous squamous cell carcinoma and its correlation with clinicopathological parameters. Methods The expression of SLP-2 in 50 cases of squamous cell carcinoma and 30 cases of seborrheic keratosis were observed by immunohistochemical method. The relationship between the expression of SLP-2 protein and clinicopathological parameters of cutaneous squamous cell carcinoma Relationship. Results The positive rates of SLP-2 protein in seborrheic keratosis and skin squamous cell carcinoma were 6.67% and 74.00%, respectively. The expression of SLP-2 protein is closely related to the pathological grade, clinical stage and lymph node metastasis of squamous cell carcinoma. Conclusion The overexpression of SLP-2 protein may be closely related to the occurrence and development of cutaneous squamous cell carcinoma.