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目的:探讨冠心病患者血清C-反应蛋白、尿酸与血脂联合检测的临床应用价值。方法:检测107例冠心病患者(40例急性心肌梗死、38例不稳定性心绞痛、29例稳定性心绞痛)血清脂类[TC、TG、HDL-C、LDL-C、ApoA、ApoB和Lp(a)]、C-反应蛋白(CRP)和尿酸(UA),并与40例健康对照组的对应指标进行比较。结果:稳定性心绞痛组、不稳定性心绞痛组和急性心肌梗死组CRP、UA、TC、TG、LDL-C、ApoB、Lp(a)水平均高于对照组;除稳定性心绞痛组的ApoA外,观察组的血清HDL-C、ApoA水平均明显低于对照组,且CRP和UA与TC、TG、LDL-C、ApoB、Lp(a)呈正相关,与HDL-C、ApoA呈负相关。结论:冠心病患者血清C-反应蛋白和尿酸与血脂代谢异常有相关性,三者联合检测对冠心病的预防、诊断及预后判断具有重要的临床价值。
Objective: To investigate the clinical value of combined detection of serum C-reactive protein, uric acid and lipids in patients with coronary heart disease. Methods: Serum lipids [TC, TG, HDL-C, LDL-C, ApoA, ApoB, and Lp were measured in 107 patients with coronary heart disease (40 with AMI, 38 with unstable angina and 29 with stable angina) a)], C-reactive protein (CRP) and uric acid (UA), and compared with the corresponding indicators of 40 healthy controls. Results: The levels of CRP, UA, TC, TG, LDL-C, ApoB and Lp (a) in stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group were all higher than those in control group. . The levels of serum HDL-C and ApoA in observation group were significantly lower than those in control group. CRP and UA were positively correlated with TC, TG, LDL-C, ApoB and Lp (a), but negatively correlated with HDL-C and ApoA. Conclusion: There is a correlation between serum C-reactive protein and uric acid in patients with coronary heart disease and dyslipidemia. The combination of these three tests has important clinical value in the prevention, diagnosis and prognosis of coronary heart disease.