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采用大鼠局部脑缺血再灌流模型，研究了大鼠脑缺血６ｈ、９ｈ和缺血６ｈ再灌流３ｈ脑梗塞体积，脑含水量，能量代谢，丙二醛（ＭＤＡ）和超氧化物歧化酶（ＳＯＤ）的变化。结果：脑缺血６ｈ、９ｈ可以造成严重的脑梗塞和脑水肿，ＡＴＰ含量和ＳＯＤ活性显著降低，乳酸和ＭＤＡ含量显著增加，和对照组相比均有显著差异（Ｐ＜０．０５或Ｐ＜０．００１）。再灌组和缺血两组比较，脑梗塞体积，脑水肿无明显差别（Ｐ＞０．０５），ＡＴＰ、乳酸、ＳＯＤ和ＭＤＡ均有不程度的改善。提示，大鼠局部脑缺血超过６ｈ可造成严重的脑损伤，并随缺血时间的再延长，脑损伤变化趋于平缓。再灌后，脑损伤未见明显加重。
The cerebral infarction volume, brain water content, energy metabolism, malondialdehyde (MDA) and superoxide dismutase (SOD) in rat brain after focal cerebral ischemia 6h, 9h and 6h after reperfusion were studied by using the model of focal cerebral ischemia- Changes in enzyme (SOD). Results: Severe cerebral infarction and cerebral edema were induced at 6h and 9h after cerebral ischemia. ATP content and SOD activity were significantly decreased, and the content of lactate and MDA significantly increased (P <0.05 or P <0.001). There were no significant differences in cerebral infarction volume and cerebral edema between reperfusion group and ischemia group (P> 0.05). ATP, lactate, SOD and MDA were all improved to a certain extent. Tip, cerebral ischemia in rats more than 6h can cause severe brain damage, and with the reperfusion time extension, changes in brain injury tends to be gentle. After reperfusion, no significant increase in brain injury.