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目的观察米非司酮配伍甲基睾丸素治疗更年期功血的疗效。方法用米非司酮12.5 mg加甲基睾丸素5 mg口服,每日1次,连服3个月,治疗前后测血清促卵泡生成激素(FSH)、促黄体生成激素(LH)、孕酮(P)、雌二醇(E2)。结果50例患者用药期间均出现闭经,6例患者停药后半年内继续闭经,44例患者月经恢复(其中32例经量比前减少,10例月经量正常),血清FSH、LH、P水平均下降。结论米非司酮配伍甲基睾丸素治疗更年期功血效果显著,副反应少,值得临床推广应用。
Objective To observe the efficacy of mifepristone combined with methyltestosterone in the treatment of climacteric dysfunctional uterine bleeding. Methods Mifepristone 12.5 mg plus methyltestosterone 5 mg orally, once daily for 3 months, before and after treatment, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), estradiol (E2). Results All patients underwent amenorrhoea during the medication period. Six patients discontinued amenorrhea within six months after drug withdrawal. Menstruation was restored in 44 patients (32 of them were reduced in volume and 10 in normal menstruation), serum FSH, LH, P levels All declined. Conclusion The combination of mifepristone and methyltestosterone in the treatment of climacteric dysfunctional uterine bleeding is effective and has few side effects. It is worthy of clinical application.