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目的研究Skp2及PTEN蛋白在膀胱移行细胞癌(膀胱癌)组织中的表达,探讨其临床意义。方法采用免疫组化方法检测在68例膀胱癌中Skp2和PTEN蛋白的表达。结果膀胱癌组织中Skp2阳性率(44.1%)显著高于膀胱正常黏膜组织(11.8%)(P<0.05),而PTEN则相反;Skp2与PTEN蛋白表达成负相关(P<0.05)。结论 Skp2蛋白表达增高与膀胱癌的临床分期、病理分级相关,且与PTEN成负相关;联合检测Skp2、PTEN可作为判定膀胱癌生物学行为的客观指标。
Objective To study the expression of Skp2 and PTEN protein in transitional cell carcinoma of the bladder (bladder transitional cell carcinoma) and to investigate its clinical significance. Methods Immunohistochemical method was used to detect the expression of Skp2 and PTEN protein in 68 cases of bladder cancer. Results The positive rate of Skp2 (44.1%) in bladder cancer was significantly higher than that in normal mucosa of bladder (11.8%) (P <0.05), while the expression of Skp2 was negatively correlated with PTEN (P <0.05). Conclusion The increased expression of Skp2 is correlated with the clinical stage and pathological grade of bladder cancer, and negatively correlates with PTEN. Combined detection of Skp2 and PTEN may be used as objective indicators to judge the biological behavior of bladder cancer.