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目的:观察益胃汤合芍药甘草汤加减联合西药治疗胃阴不足型慢性萎缩性胃炎(CGA)证的疗效及对血清胃泌素(GS)水平的影响。方法:选择我院收治CAG患者60例,随机分为治疗组和对照组,每组均30例。对照组给予吗丁啉片,乳酶生片治疗,治疗组在对照组基础上给予益胃汤合芍药甘草汤加减治疗,两组患者连续治疗12周。比较两组中医(TCM)证候相关症状评分、胃黏膜组织病理改变评分及临床疗效;检测两组血清GS水平。结果:治疗后,治疗组TCM证候症状及黏膜炎症、腺体减少、炎症活动度及肠上皮化生评分明显少于对照组(P<0.01)。治疗组总有效率为93.33%,显著高于对照组为66.67%(P<0.05)。治疗后,治疗组血清GS水平显著高于对照组,差异有统计学意义(P<0.01)。结论:益胃汤合芍药甘草汤加减联合吗丁啉治疗胃阴不足型CGA证的疗效明显,上调患者血清GS水平可能是其作用机制之一。
Objective: To observe the therapeutic effect of Yishenthe Shaoyao Gancao Decoction combined with western medicine in the treatment of chronic atrophic gastritis (CGA) with gastric-yin insufficiency and its effect on serum gastrin (GS). Methods: Sixty patients with CAG admitted to our hospital were randomly divided into treatment group and control group, with 30 cases in each group. The control group was treated with domperidone tablets and lactase tablets. The treatment group was treated with Yiwei Decoction and Shaoyao Gancao Decoction on the basis of the control group, and the two groups were treated for 12 weeks continuously. The TCM symptom score, gastric mucosal histopathological score and clinical curative effect were compared between two groups. Serum GS level was measured in both groups. Results: After treatment, TCM symptoms and mucosal inflammation, gland reduction, inflammatory activity and intestinal metaplasia score in the treatment group were significantly less than those in the control group (P <0.01). The total effective rate in the treatment group was 93.33%, which was significantly higher than that in the control group (66.67%, P <0.05). After treatment, serum GS level in the treatment group was significantly higher than that in the control group (P <0.01). Conclusion: Yiwei Decoction combined peony Decoction Decoction combined with domperidone in the treatment of gastric insufficiency CGA obvious effect, up-regulation of serum GS levels may be one of its mechanisms.