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趋化因子在免疫调节、血管新生以及介导肿瘤的器官特异性转移中发挥重要作用。其中CXC趋化因子超家族由于N-端谷氨酸-亮氨酸-精氨酸基序(Glu-Leu-Arg,ELRmotif)的有无使其在血管新生过程中具有了促进或者抑制血管新生的不同作用:含有ELR(ELR+)的CXC趋化因子经血管内皮组织上CXCR2介导血管新生促进作用;而不含有ELR(ELR-)的CXC趋化因子通过血管内皮组织上CXCR3介导血管新生抑制作用。
Chemokines play an important role in immune regulation, angiogenesis, and in mediating organ-specific metastases of tumors. Which CXC chemokine superfamily due to the N-terminal glutamate - leucine - Arginine (Arg, ELRmotif) whether or not it has in the process of angiogenesis to promote or inhibit angiogenesis : CXC chemokines containing ELR (ELR +) mediate CXCR2-mediated angiogenic effects on vascular endothelial tissue whereas CXC chemokines not containing ELR (ELR-) mediate CXCR3-mediated angiogenesis on vascular endothelium Inhibition.