目的:减轻人工流产手术时使用米索前列醇孕妇的术后疼痛,减少人工流产手术并发症的发生。方法:选择120例使用米索前列醇的无痛人工流产患者,ASAⅠ~Ⅱ级,随机分为两组,每组各60例,两组均用丙泊酚和瑞芬太尼实施无痛人工流产麻醉。实验组术前90 min口服氨酚羟考酮1粒,对照组术前不服用任何止痛剂。记录两组围手术期各个时点的视觉疼痛评分(VAS评分)及不良反应发生率。结果:实验组术后5、10、20 min的VAS评分低于对照组,差异有统计学意义(P<0.05),两组不良反应发生率及术中出血量比较差异无统计学意义(P>0.05)。两组人工流产综合征发生率比较差异有统计学意义(P<0.05)。结论:实验组术后镇痛效果显著,可有效降低使用米索前列醇产生的子宫收缩痛。人工流产手术常见并发症的发生率降低。联合用药为术后镇痛提供了新的选择。 OBJECTIVE: To reduce postoperative pain in misoprostol pregnant women during abortion, and to reduce the incidence of complications of induced abortion. Methods: A total of 120 patients with misoprostol induced misoprostol (ASA Ⅰ ~ Ⅱ) were randomly divided into two groups of 60 patients in each group. Both groups were given painless artificial propofol and remifentanil Abortion anesthesia. In the experimental group, one tablet of paracetamol and oxycodone was orally administered 90 min before operation, and the control group did not take any analgesic before operation. The visual acuity scores (VAS scores) and the incidence of adverse reactions at each time point were recorded. Results: The VAS scores at 5, 10 and 20 min after operation in the experimental group were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions and blood loss between the two groups (P > 0.05). The incidence of two groups of abortion syndrome was significantly different (P <0.05). Conclusion: The postoperative analgesic effect of the experimental group is significant, which can effectively reduce the uterine contractions pain caused by using misoprostol. The incidence of common complications of induced abortion decreased. Combination therapy provides a new option for postoperative analgesia.