目的从细胞和基因水平阐明大蒜油对人胃癌ＢＧＣ８２３细胞的作用机制．方法用激光扫描共聚焦显微镜及Ｎｏｒｔｈｅｒｎ杂交等技术进行分析．结果大蒜油对癌细胞形态、增殖和致瘤性有明显影响．结论首次发现大蒜油对肿瘤细胞的作用是通过影响ｐ５３，ｐ２１等的表达水平．以上结果提示大蒜油有诱导肿瘤细胞分化的作用． Objective To elucidate the mechanism of garlic oil on human gastric cancer BGC823 cells from the level of cells and genes. 2. The method was analyzed by laser scanning confocal microscope and Northern hybridization. Results Garlic oil had significant effects on the morphology, proliferation and tumorigenicity of cancer cells. Conclusion The effect of garlic oil on tumor cells was discovered for the first time by affecting the expression levels of p53, p21 and so on. The above results suggest that garlic oil can induce the differentiation of tumor cells.