论文部分内容阅读
自噬(autophagy)是继凋亡后,当前生命科学最热的研究领域之一。比利时科学家Christian deDuve在1955年通过电镜观察到了自噬体结构,并在1963年的溶酶体国际会议上首先提出了“自噬”这种说法,但最近几年才开始阐明自噬过程的某些分子机制。正常情况下细胞内的自噬处于低水平,当受到饥饿、营养缺乏、缺氧应激等外界环境刺激时自噬被激活[1],以利于细胞存活,但当自噬水平过
Autophagy is one of the hottest areas of current life science following apoptosis. Belgian scientist Christian de Duve observed the autophagosome structure by electron microscopy in 1955 and first proposed “autophagy” at the International Conference on Lysosomes in 1963, but only in recent years has elucidated the process of autophagy Some of the molecular mechanisms. Under normal circumstances, autophagy is at a low level, and autophagy is activated when stimulated by external environment such as starvation, nutritional deficiencies and hypoxia stress [1], in order to facilitate cell survival, but when the level of autophagy is too low