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目的：探讨ｐ１６蛋白表达在软骨肉瘤诊断、分级和预后中的临床意义。方法：分析ｐ１６蛋白表达与良、恶性软骨肿瘤和软骨肉瘤病理分级间以及与软骨肉瘤不同临床病理因素间的关系。结果：（１）ｐ１６表达与软骨肉瘤组织学分级显著相关（ Ｐ＜ ０．０５），且在软骨肉瘤不同组织学分级间 ｐ１６蛋白表达差异有显著性（ Ｐ＜ ０． ０５）。（２）ｐ１６表达在软骨肉瘤体积、复发方面差异有显著性（Ｐ＜ ０．０５）。结论： （１） ｐ１６在软骨肉瘤形成和发展中起不同程度的作用。（２）ｐ１６蛋白表达对软骨肉瘤组织学分级、恶性进展和预后判断有指导意义。
Objective: To explore the clinical significance of p16 protein expression in the diagnosis, grading and prognosis of chondrosarcoma. Methods: The relationship between the expression of p16 protein and the pathological grades of benign and malignant cartilage tumors and chondrosarcoma and the different clinicopathological factors of chondrosarcoma were analyzed. RESULTS: (1) The expression of p16 was significantly associated with the histological grade of chondrosarcoma (P < 0.05), and there was a significant difference in the expression of p16 protein between different histological grades of chondrosarcoma (P < 0.05). (2) There was a significant difference in the volume and recurrence of chondrosarcoma with p16 expression (P < 0.05). Conclusion: (1) p16 plays a different role in the formation and development of chondrosarcoma. (2) p16 protein expression has guiding significance for the histological grade, malignant progression and prognosis of chondrosarcoma.