【摘 要】
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Objective To evaluate the effect of the aluminum hydroxide (AI-OH) adjuvant on the 2009 pandemic influenza A/H1N1 (pH1N1) vaccine.Methods In a multicenter,doubl
【机 构】
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Chinese Center for Disease Control and Prevention,Chinese Field Epidemiology Training Program
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Objective To evaluate the effect of the aluminum hydroxide (AI-OH) adjuvant on the 2009 pandemic influenza A/H1N1 (pH1N1) vaccine.Methods In a multicenter,double-blind,randomized,placebo-controlled trial,participants received two doses of split-virion formulation containing 15 μg hemagglutinin antigen,with or without aluminum hydroxide (AI-OH).We classified the participants into six age categories (＞61 years,41-60 years,19-40 years,13-18 years,8-12 years,and 3-7 years) and obtained four blood samples from each participant on days O,21,35,and 42 following the first dose of immunization.We assessed vaccine immunogenicity by measuring the geometric mean titer (GMT) of hemagglutination inhibiting antibody.We used a two-level model to evaluate the fixed effect of aluminum AI-OH and other factors,accounting for repeated measures.Results The predictions of repeated measurement on GMTs of formulations with or without AI-OH,were 80.35 and 112.72,respectively.AI-OH significantly reduced immunogenicity after controlling for time post immunization,age-group and gender.Conclusion The AI-OH adjuvant does not increase but actually reduces the immunogenicity of the split-virion pH1N1 vaccine.
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