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目的：观察血管通透性在脊髓受压后的改变和益气化瘀利水方药的药理机制。方法：通过注射１０６ Ｗ ａｌｋｅｒ ２５６ 瘤细胞液到大鼠 Ｔ１３ 椎体前，建立脊髓硬膜外压迫实验模型，通过伊文思蓝法定量测定脊髓血管通透性。结果：脊髓受压后血管通透性明显升高（ Ｐ＜ ０．０１），消炎痛和益气化瘀利水方药能明显抑制血管通透性，但消炎痛的作用强于益气化瘀利水方药（ Ｐ＜ ０．０１），颈痛灵对血管通透性则无影响（ Ｐ＞ ０．０５）。结论：脊髓受压后的水肿为血管源性水肿，益气化瘀利水方药通过减轻水肿，来延缓脊髓继发性损害的产生。
Objective: To observe the changes of vascular permeability after spinal cord compression and the pharmacological mechanisms of Yiqi Huayu Lishui formulae. METHODS: An experimental model of spinal cord epidural compression was established by injecting 106 W alker 256 tumor cell fluid into the rat T13 vertebral body, and the vascular permeability of the spinal cord was quantified by the Evans blue method. RESULTS: The vascular permeability was significantly increased after spinal cord compression (P<0.01). Indomethacin and Yiqi Huayu Lishui Prescriptions can significantly inhibit vascular permeability, but the effect of indomethacin is stronger than that of qi and saliva. Prescription (P<0.01), Nuantongling had no effect on vascular permeability (P> 0.05). Conclusion: The edema after compression of the spinal cord is vasogenic edema. Yiqi Huayu Lishui Prescription can delay the occurrence of secondary spinal cord injury by reducing edema.