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目的探讨氟喹诺酮类药物导致的不良反应发生的临床特点。方法 2010年1月至12月,总结分析我院收治的144例氟喹诺酮类药物出现不良反应患者的临床资料,并进行数据统计学分析。结果 38～58岁是氟喹诺酮类药物不良反应发生的主要年龄段,明显高于其他年龄段(P<0.05);临床表现主要以损害神经系统为主,男性发生率明显高于女性的发生率(P<0.05)。结论应用氟喹诺酮类药物时要充分认识其不良反应发生情况,注意对可能发生的不良反应的预防,降低不良反应的发生率,同时今后应重视总结新一代氟喹诺酮药物的不良反应发生规律。
Objective To investigate the clinical characteristics of fluoroquinolone-induced adverse reactions. Methods From January to December 2010, the clinical data of 144 patients with adverse reactions of fluoroquinolones admitted in our hospital were analyzed and analyzed statistically. Results 38 to 58 years old were the major age groups of adverse reactions of fluoroquinolones, which were significantly higher than those of other age groups (P <0.05). The main clinical manifestations were the damage to nervous system, and the incidence of male was significantly higher than that of female (P <0.05). Conclusion Fluoroquinolones should fully understand the occurrence of adverse reactions, pay attention to the prevention of possible adverse reactions, reduce the incidence of adverse reactions, and should pay attention to summarize the occurrence of adverse reactions of the new generation of fluoroquinolones in the future.