消炎痛(IM)在临床上具有较好的镇痛消炎作用,但是由于其副作用多,发生率多达35～50％,主要表现为消化道症状和中枢症状。这主要是由于消炎痛抑制胃粘膜前列腺素合成及血药浓度峰谷波动较大的缘故。因此,限制了消炎痛的临床使用。为了提高消炎痛的临床效果,降低和减少副作用的发生,近年来国内外广大药学工作者对其剂型进行了多方面的研究,现综述如下。 Indomethacin (IM) has a good analgesic and anti-inflammatory effect in clinical practice, but due to its side effects, the incidence rate is as high as 35% to 50%. The main manifestations are gastrointestinal symptoms and central symptoms. This is mainly due to indomethacin inhibition of gastric mucosal prostaglandin synthesis and blood concentration fluctuations in the larger peaks and valleys. Therefore, the clinical use of indomethacin is limited. In order to improve the clinical effect of indomethacin, reduce and reduce the incidence of side effects in recent years, the majority of domestic and foreign pharmaceutical workers conducted a multi-faceted study of their dosage forms, are summarized below.