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正常情况下,为了维持餐后血糖的稳定,α和β细胞的作用是相反的,胰岛α细胞刺激胰岛素分泌同时β细胞抑制胰高血糖素分泌,从而降低血糖水平。2型糖尿病(T2DM)患者中α和β细胞间的相互作用失调,T2DM就是以胰岛素第一时相分泌缺失~([1])以及胰高血糖素释放不受抑制~([2,3])为特征的一种疾病。胰升血糖素样肽-1(GLP-1)是胃肠道产生的一种肠促胰素,并在进餐时释放。GLP-1以血糖依赖的方式刺激胰岛素分泌及抑制胰高血糖素分泌~([4,5]),而且能够有效的抑制餐时高血糖~([6])。利拉鲁肽是
Under normal circumstances, in order to maintain the stability of postprandial blood glucose, the role of α and β cells is the opposite, islet α cells stimulate insulin secretion while β cells inhibit glucagon secretion, thereby reducing blood glucose levels. The interaction between alpha and beta cells is dysfunctional in patients with type 2 diabetes mellitus (T2DM). T2DM is characterized by a lack of first phase insulin secretion (1) and no inhibition of glucagon release (2,3) ) Is characterized by a disease. Glucagon-like peptide-1 (GLP-1) is an incretin produced in the gastrointestinal tract and released on meal. GLP-1 stimulates insulin secretion and inhibits glucagon secretion in a glucose-dependent manner (4,5) but also effectively suppresses hyperglycemia during mealtime (6). Liraglutide is