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[目的]分析恶性肿瘤患者经外周中心静脉置管术(PICC)相关性血栓形成的临床特征,为早期预防PICC相关性血栓形成提供科学依据。[方法]选取符合PICC置管要求的207例恶性肿瘤患者进行分析,采用酶联免疫吸附法分别检测血浆D-二聚体(D-Dimer)、凝血酶原片段1+2(F1+2)、血栓调节蛋白(TM)等指标。[结果]207例恶性肿瘤PICC相关性血栓形成发生率为15.9%。与无血栓组相比,血栓组D-Dimer(0.784±0.336)、F1+2(523.609±123.234)、TM(6.806±1.805)均明显升高(P<0.05)。D-Dimer(r=0.429)、F1+2(r=0.644)及TM(r=0.401)与PICC相关性血栓形成呈正相关性。多因素Logistics分析结果显示D-Dimer、F1+2、TM是恶性肿瘤PICC相关性血栓形成的独立危险因素。[结论]D-Dimer、F1+2及TM三者水平的升高对PICC相关性血栓形成的早期诊断可能具有一定的临床价值。
[Objective] To analyze the clinical features of periprocedural catheterization (PICC) -associated thrombosis in patients with malignant tumors and provide a scientific basis for the early prevention of PICC-related thrombosis. [Methods] A total of 207 patients with malignant tumor meeting the PICC catheterization criteria were selected for analysis. Plasma D-dimer and prothrombin fragment 1 + 2 (F1 + 2) were detected by enzyme linked immunosorbent assay (ELISA) , Thrombomodulin (TM) and other indicators. [Results] The incidence of PICC-related thrombosis in 207 malignant tumors was 15.9%. D-Dimer (0.784 ± 0.336), F1 + 2 (523.609 ± 123.234) and TM (6.806 ± 1.805) in thrombosis group were significantly higher than those in thrombosis group (P <0.05). D-Dimer (r = 0.429), F1 + 2 (r = 0.644) and TM (r = 0.401) were positively correlated with PICC-related thrombosis. Multivariate Logistic analysis showed that D-Dimer, F1 + 2 and TM were independent risk factors for PICC-related thrombosis in malignant tumors. [Conclusion] Elevated levels of D-Dimer, F1 + 2 and TM may have some clinical value for the early diagnosis of PICC-related thrombosis.