曾报道,棉酚-吡咯烷酮(PVP)共沉物具有较强的体外杀精子作用。本文报道棉酚-PVP共沉物对在体猴(Macaca arctoides)阴道杀精子作用的结果。(1)棉酚-PVP共沉物的制备:先将分析纯棉酚溶解于少量乙醚中,然后用甲醇稀释至0.01g/ml。PVP用小体积甲醇溶解,将棉酚和PVP两溶液混合(4gPVP:1g棉酚),在旋转蒸发器中挥尽溶剂,得棉酚-PVP共沉物; It has been reported that gossypol-pyrrolidone (PVP) co-precipitates have a strong in vitro spermicidal effect. This article reports the results of vaginal spermicidal effects of gossypol-PVP co-precipitates on Macaca arctoides. (1) Preparation of gossypol-PVP coprecipitate: The analytical gossypol was first dissolved in a small amount of diethyl ether and then diluted to 0.01 g / ml with methanol. PVP was dissolved in a small volume of methanol, gossypol and PVP two solutions were mixed (4gPVP: 1g gossypol), the solvent was evaporated in a rotary evaporator to give gossypol-PVP coprecipitate;